Researchers recently developed a new approach for identifying new cellular RNA targets of snoRNAs. They uncovered thousands of previously unknown targets for snoRNAs in human cells and mouse brain ...

Dynamic, reversible modifications of DNA and RNA regulate how genes are expressed and transcribed, which can influence cellular processes, disease development, and overall organismal health. Small ...

Peking University, June 27, 2025: To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian cells, researchers from Peking University ...

While the COVID-19 vaccines introduced many people to RNA-based medicines, RNA oligonucleotides have already been on the market for years to treat diseases like Duchenne Muscular Dystrophy and ...

This work presents a redox-responsive strategy for precise RNA control via post-synthetic 2′-OH acylation. These introduced disulfide-containing acyl groups can be selectively cleaved upon exposure to ...

RNA is a central biological macromolecule, now widely harnessed in medicine and nanotechnology. Like proteins, RNA function often depends on its precise three-dimensional structure. A recent study ...

RNA drugs are the next frontier of medicine, but manufacturing them requires an expensive and labor-intensive process that limits production and produces metric tons of toxic chemical waste.

Scientists have identified an RNA-based sperm aging clock driven by rsRNA length changes, which may help assess paternal ...

Across all domains of life, immune defenses thwart invading viruses by making it impossible for the viruses to replicate. Most known CRISPR systems target invading pathogens’ DNA and chop it up to ...