Signaling through the TREM2 receptor fuels an ever-growing list of known microglial functions in the brain, and gene variants that hobble TREM2 signaling beckon Alzheimer’s disease. Ergo, activating ...

The protein TREM2, which in humans is encoded by the TREM2 gene, is known to play a crucial role in the growth and development of different types of immune cells, including microglia. Microglia are ...

Certain mutations in TREM2 strongly increase risk for late-onset Alzheimer’s. Could tweaking the function of this microglial receptor help people with the disease? A new study suggests as much. In the ...

A new study has investigated the mechanisms by which the receptor TREM2 affects atherosclerosis and a possible therapeutic approach using an agonistic TREM2 antibody. Atherosclerosis is a chronic ...

WATERTOWN, Mass., Oct. 17, 2023 (GLOBE NEWSWIRE) -- Vigil Neuroscience, Inc. (Nasdaq: VIGL), a clinical-stage biotechnology company committed to harnessing the power of microglia for the treatment of ...

WATERTOWN, Mass., April 02, 2025 (GLOBE NEWSWIRE) -- Vigil Neuroscience, Inc. (Nasdaq: VIGL), a clinical-stage biotechnology company committed to harnessing the power of microglia for the treatment of ...

Alzheimer’s disease is a genetically complex and heterogeneous disorder. Genomewide association studies aimed at identifying gene variants that influence the risk of Alzheimer’s disease have ...

Recently, teams led by Prof. Yiming Zhang from Xinqiao Hospital, Army Medical University,Prof. Fazhi Qi from Zhongshan Hospital, Fudan University, and Prof. Junli Zhou from the Tenth Affiliated ...

Upon recognition of candidalysin, TREM2 recruits the adaptor protein DAP12 to activate Syk kinase, subsequently phosphorylate NF-κB p65 and MAPK p38, and ultimately lead to the secretion of TNF-α. TNF ...

In a mouse study, researchers have found that an antibody that targets the protein TREM2 empowers tumor-destroying immune cells and improves the effectiveness of cancer immunotherapy. Immunotherapy ...